Journal Article

Atherosclerosis and Infection Due to <i>Chlamydia pneumoniae</i> or Cytomegalovirus: Weighing the Evidence

Kevin P. High

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 28, issue 4, pages 746-749
Published in print April 1999 | ISSN: 1058-4838
Published online April 1999 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/515216
Atherosclerosis and Infection Due to Chlamydia pneumoniae or Cytomegalovirus: Weighing the Evidence

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A link between infectious agents and atherosclerosis has been postulated for decades. This review describes the epidemiological and biological evidence linking cytomegalovirus and Chlamydia pneumoniae to atherosclerotic disease. Case-control studies and histologic evidence from atheromatous specimens support an association between atherosclerosis and infection with these two microorganisms, and small interventional trials appear to confirm the link with C. pneumoniae, but these findings require confirmation in larger studies. A lack of clinically relevant animal models has hampered investigations regarding biological mechanisms, particularly for C. pneumoniae.

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Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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