Journal Article

Effectiveness of Clemastine Fumarate for Treatment of Rhinorrhea and Sneezing Associated with the Common Cold

Ronald B. Turner, Steven J. Sperber, James V. Sorrentino, Robert R. O'Connor, James Rogers, Amir Reza Batouli and Jack M. Gwaltney

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 25, issue 4, pages 824-830
Published in print October 1997 | ISSN: 1058-4838
Published online October 1997 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/515546
Effectiveness of Clemastine Fumarate for Treatment of Rhinorrhea and Sneezing Associated with the Common Cold

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Limited data support the use of first-generation antihistamines for treatment of the common cold. The purpose of this study was to test the effectiveness of clemastine fumarate, a first-generation antihistamine, for treatment of sneezing and rhinorrhea associated with naturally occurring common colds. Four hundred three subjects (202 clemastine fumarate recipients and 201 placebo recipients) who reported new onset (<24 hours) of cold symptoms that included rhinorrhea or sneezing were studied. At baseline (day 1), the mean symptom-severity scores ± SEM for the clemastine fumarate and placebo groups were not significantly different. The mean rhinorrhea-severity score ± SEM was not different on day 2; however, on day 3, the mean rhinorrhea-severity score ± SEM was 1.02 ± 0.07 for the clemastine fumarate group and 1.39 ± 0.07 for the placebo group (P < .001). This treatment effect persisted on day 4. A significant effect on sneezing was noted on days 2–4. Sedation occurred in 14% of the clemastine fumarate-treated subjects and 1.5% of the placebo-treated subjects (P < .0001).

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Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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