Journal Article

Point Prevalence of Oropharyngeal Carriage of Fluconazole-Resistant <i>Candida</i> in Human Immunodeficiency Virus-Infected Patients

Marcelo D. Martins, Mario Lozano-Chiu and John H. Rex

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 25, issue 4, pages 843-846
Published in print October 1997 | ISSN: 1058-4838
Published online October 1997 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/515554
Point Prevalence of Oropharyngeal Carriage of Fluconazole-Resistant Candida in Human Immunodeficiency Virus-Infected Patients

More Like This

Show all results sharing these subjects:

  • Infectious Diseases
  • Immunology
  • Public Health and Epidemiology
  • Microbiology

GO

Show Summary Details

Preview

To estimate the prevalence of both clinically evident and asymptomatic carriage of fluconazole-resistant Candida, we prospectively surveyed 128 adults infected with human immunodeficiency virus (HIV). The patients had an average CD4 cell count of 206/mm3. Ninety-seven isolates of Candida were obtained from the oropharynx of 82 patients (64%). Of these 82 patients, 76% carried C. albicans alone; 18%, both albicans and non-albicans isolates; and 6%, non-albicans species alone. Oropharyngeal candidiasis was evident in only 38 (46%) of the 82 patients for whom a culture was positive and was never seen unless C. albicans was present. When MICs were measured by using the National Committee for Clinical Laboratory Standards M27-T methodology and grouped by using recently proposed breakpoints, we found that eight of the 38 patients with oropharyngeal candidiasis and six of the 44 patients who were asymptomatically colonized carried C. albicans isolates resistant to fluconazole (MIC, ⩾64 µg/mL); estimated rates of carriage were 21% (95% confidence interval, 10%–37%) and 14% (95% confidence interval, 5%-27%), respectively. Carriage of resistant isolates of C. albicans by HIV-infected adults is more common than previously suspected, and clinicians should be alert to the possible need for either higher doses of fluconazole or alternative treatment modalities.

Journal Article.  0 words. 

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.