Journal Article

Acquired Drug Resistance in Mycobacterium tuberculosis Isolates Recovered from Compliant Patients with Human Immunodeficiency Virus-Associated Tuberculosis

Francesca March, Xavier Garriga, Purificación Rodríguez, Carmen Moreno, Montserrat Garrigó, Pere Coll and Guillem Prats

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 25, issue 5, pages 1044-1047
Published in print November 1997 | ISSN: 1058-4838
Published online November 1997 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/516065
Acquired Drug Resistance in Mycobacterium tuberculosis Isolates Recovered from Compliant Patients with Human Immunodeficiency Virus-Associated Tuberculosis

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We describe five compliant patients with human immunodeficiency virus (HIV)-associated tuberculosis (TB) that relapsed, with acquisition of resistance by the original Mycobacterium tuberculosis strains. Both the first and second isolates from each patient had the same IS (insertion sequence) 6110-based DNA fingerprint patterns. Three of the five patients developed TB that was resistant to rifampin alone; no mutation in the region of the rpoB gene was detected by a line probe assay in two of the isolates from these patients. We discuss several factors presumably associated with acquired drug resistance in HIV-infected patients, including exogenous reinfection, drug interactions, malabsorption of drugs, and the presence of a large organism burden.

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Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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