Journal Article

Quinolone Arthropathy in Animals Versus Children

John E. Burkhardt, Juan N. Walterspiel and Urs B. Schaad

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 25, issue 5, pages 1196-1204
Published in print November 1997 | ISSN: 1058-4838
Published online November 1997 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/516119
Quinolone Arthropathy in Animals Versus Children

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The use of quinolones in children and accumulation of data on the pharmacodynamics of these drugs have been limited and delayed by concern regarding their chondrotoxicity. A comprehensive review of the findings in animals compared with the cumulative published findings in children and adolescents (>7,000 to date) allows the conclusion that such concern is not justified. Prospective controlled studies in children are justifiable in view of a continuing lack of correlation between findings in juvenile animals and those in children and because of the selected therapeutic advantages of the current and newer quinolones.

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Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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