Journal Article

Fluorescent Antibody Test for Rabies: Prospective Study of 8,987 Brains

Veera Tepsumethanon, Boonlert Lumlertdacha, Channarong Mitmoonpitak, Robert Fagen and Henry Wilde

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 25, issue 6, pages 1459-1461
Published in print December 1997 | ISSN: 1058-4838
Published online December 1997 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/516151
Fluorescent Antibody Test for Rabies: Prospective Study of 8,987 Brains

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A prospective study of 8,987 canine, feline, human, and other mammalian brains (and one avian brain) was undertaken. The brains were analyzed for rabies antigens; two samples were obtained from each brainstem, and one sample was obtained from each hippocampus. The samples were stained with rabies conjugate and examined by use of fluorescence microscopy. There were no falsenegative results. We conclude, therefore, that postexposure rabies treatment is not requisite in all cases, provided that the fluorescent antibody test is performed without delay in a laboratory experienced with the procedure and microscopy results are fluorescent negative.

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Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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