Journal Article

The Cold Zone: A Curious Convergence of Tick-Transmitted Diseases

David H. Persing

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 25, issue Supplement_1, pages S35-S42
Published in print July 1997 | ISSN: 1058-4838
Published online July 1997 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/516170
The Cold Zone: A Curious Convergence of Tick-Transmitted Diseases

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In recent years, investigators have gained an increasing appreciation of the complexity of the Lyme disease transmission cycle with regard to the number of pathogens involved. Babesia microti, a blood parasite that is related to the organism that causes malaria, frequently accompanies the Lyme disease spirochete in the mouse reservoir. Recently, a newly described Ehrlichia species related to Ehrlichia equi has been found to be transmitted by the deer tick. Human infections with these agents alone and in combination are now being described, and the successful treatment of these infections may depend on proper diagnosis. The convergence of these and other organisms on the Lyme disease transmission cycle provides a unique opportunity to study pathogen-pathogen interactions in a naturally occurring model.

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Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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