Journal Article

Follow-up of 18 Patients with Human Immunodeficiency Virus Infection and Chronic Chagas' Disease, with Reactivation of Chagas' Disease Causing Cardiac Disease in Three Patients

Ana Marli C. Sartori, Maria A. Shikanai-Yasuda, Vicente Amato Neto and Marta H. Lopes

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 26, issue 1, pages 177-179
Published in print January 1998 | ISSN: 1058-4838
Published online January 1998 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/516257
Follow-up of 18 Patients with Human Immunodeficiency Virus Infection and Chronic Chagas' Disease, with Reactivation of Chagas' Disease Causing Cardiac Disease in Three Patients

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A series of 18 patients with chronic Chagas' disease and human immunodeficiency virus infection were followed up for 2 to 66 months (median, 15.5 months). Artificial xenodiagnosis was positive for 81.3% and natural xenodiagnosis was positive for 81.8% of patients for whom they were performed; 81.8% of 11 patients had medium- or high-level parasitemia. Reactivation of Chagas' disease—direct microscopic examination of blood revealing parasites and, clinically, patients presenting with cardiac disease—occurred in three patients (16.7%). Specific antitrypanosomal treatment with benznidazole was effective in reducing the level of parasitemia and improving the clinical condition in three of the four patients treated.

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Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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