Journal Article

Acyclovir Use and Survival Among Human Immunodeficiency Virus-Infected Patients with CD4 Cell Counts of <500/mm<sup>3</sup>

Ramón A. Torres, James D. Neaton, Deborah N. Wentworth, Michael R. Barr, Donald Abrams, Renslow Sherer, Thomas Ward and James Sampson

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 26, issue 1, pages 85-90
Published in print January 1998 | ISSN: 1058-4838
Published online January 1998 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/516272
Acyclovir Use and Survival Among Human Immunodeficiency Virus-Infected Patients with CD4 Cell Counts of <500/mm3

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To examine the relationship between acyclovir use and survival in AIDS, we performed a retrospective analysis of data collected through an observational cohort of the 17-site Community Program for Clinical Research on AIDS (CPCRA), under the sponsorship of the National Institute of Allergy and Infectious Diseases. Data were analyzed regarding 2,368 patients with CD4+ lymphocyte counts of <500/mm3, and 7,836 follow-up visits were conducted from September 1990 to July 1994. Factors associated with use of acyclovir were studied by stratified analysis of variance and Mantel- Haenzel χ2 tests. The association between acyclovir and survival was studied with use of the proportional hazards regression model. Individuals reporting acyclovir use were more likely to be white, male, and homosexual; to have a history of herpes simplex and zoster; and to have lower CD4+ T cell counts than those who did not. After adjustments for differences in baseline factors, acyclovir use was not associated with prolonged survival.

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Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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