Journal Article

Chlamydia trachomatis Genotypes: Correlation with Clinical Manifestations of Infection and Patients' Characteristics

Y. T. H. P. van Duynhoven, J. M. Ossewaarde, R. P. Derksen-Nawrocki, W. I. van der Meijden and M. J. W. van de Laar

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 26, issue 2, pages 314-322
Published in print February 1998 | ISSN: 1058-4838
Published online February 1998 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/516291
Chlamydia trachomatis Genotypes: Correlation with Clinical Manifestations of Infection and Patients' Characteristics

More Like This

Show all results sharing these subjects:

  • Infectious Diseases
  • Immunology
  • Public Health and Epidemiology
  • Microbiology

GO

Show Summary Details

Preview

In 1994 Chlamydia trachomatis specimens from 175 men and 135 women attending a clinic for treatment of sexually transmitted disease were genotyped by polymerase chain reaction-based restriction fragment length polymorphism of the omp1 gene. Information about the patients was collected at their initial visit. The associations between C. trachomatis genotype and patients' selfreported symptoms, clinical signs, and characteristics were studied. Genotypes E, F, and D/Dpredominated (men: 71%; women: 60%). Five specimens (1.6%) showed evidence of mixed infections. Among men, complaints of urethral discharge and dysuria were most commonly associated with genotypes H and J (100% vs. 59%–68% for the other genotypes; P = .03); in addition, ⩾10 leukocytes per microscopic field were least often observed for genotypes G/Ga (19% vs. 59%–65% for the other genotypes; P = .01). Women's reports of lower abdominal pain were more often associated with F, G group genotypes (32%) than with B-complex (6%) or C-complex (13%) genotypes (P = .02). Certain symptoms of genital C. trachomatis infection were related to the infecting genotype. Further work will be necessary and should involve markers of the host immune response.

Journal Article.  0 words. 

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.