Journal Article

A Continuing Outbreak of Multidrug-Resistant Tuberculosis, with Transmission in a Hospital Nursery

Beth Nivin, Peter Nicholas, Mitchell Gayer, Thomas R. Frieden and Paula I. Fujiwara

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 26, issue 2, pages 303-307
Published in print February 1998 | ISSN: 1058-4838
Published online February 1998 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/516296
A Continuing Outbreak of Multidrug-Resistant Tuberculosis, with Transmission in a Hospital Nursery

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We investigated an increase in cases of multidrug-resistant tuberculosis (MDRTB) at a large urban facility where a prior nosocomial outbreak of MDRTB had occurred. Nosocomial transmission appeared to account for this outbreak as well, including a cluster of cases in a newborn nursery. Seven of 24 patients (29%) described in this investigation may have been exposed in the hospital nursery during an approximately 2-week period. We believe this to be the first documented outbreak of MDRTB in a hospital nursery. The transmission in the nursery demonstrates that the possibility of exposure to unrecognized active tuberculosis in nursery and hospital personnel is always present. Infection and active disease in the infants developed after a relatively short period of exposure. These findings underscore the need for adherence to published infection control guidelines in health care settings.

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Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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