Journal Article

In Vitro Isolation and Characterization of a Calicivirus Causing a Vesicular Disease of the Hands and Feet

A. W. Smith, E. S. Berry, D. E. Skilling, J. E. Barlough, S. E. Poet, T. Berke, J. Mead and D. O. Matson

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 26, issue 2, pages 434-439
Published in print February 1998 | ISSN: 1058-4838
Published online February 1998 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/516311
In Vitro Isolation and Characterization of a Calicivirus Causing a Vesicular Disease of the Hands and Feet

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We report that a calicivirus of oceanic origin, San Miguel sea lion virus serotype 5 (SMSV-5), is a human pathogen. This biotype was isolated originally from blisters on the flippers of northern fur seals (Callorhinus ursinus) and replicates readily in primate and human cell lines. It infects a phylogenetically diverse array of hosts (poikilotherms to primates) and induces type-specific neutralizing antibodies in exposed humans. Group antibody against a pooled antigen of SMSV-5 and two other serotypes was also observed in 18% of 300 blood donors from a population in the northwestern United States. The human calicivirus isolate designated SMSV-5 Homosapien-1 (SMSV-5 Hom-1) was recovered from a laboratory worker with systemic illness, including vesicular lesions on all four extremities. We believe this newly described human disease represents a paradigmatic shift in calicivirus disease recognition.

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Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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