Journal Article

The 30-bp Deletion Variant of Epstein-Barr Virus-Encoded Latent Membrane Protein-1 Prevails in Acute Infectious Mononucleosis

Christoph Berger, Cathy McQuain, John L. Sullivan, David Nadal, Peter J. Quesenberry and Hans Knecht

in The Journal of Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 176, issue 5, pages 1370-1373
Published in print November 1997 | ISSN: 0022-1899
Published online November 1997 | e-ISSN: 1537-6613 | DOI: http://dx.doi.org/10.1086/517324
The 30-bp Deletion Variant of Epstein-Barr Virus-Encoded Latent Membrane Protein-1 Prevails in Acute Infectious Mononucleosis

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To assess the frequency of malignancy-associated 30-bp deletion variants of the latent membrane protein 1 (LMP-1) in benign conditions, a comparative sequence analysis was done using samples from 20 American children with acute infectious mononucleosis and 16 Swiss children with chronic tonsillar hyperplasia. The 30-bp deletion variant (LMP-1-del) was present in 66% of patients (12/20 with infectious mononucleosis and 12/16 with tonsillar hyperplasia). Two additional patients had a 3-bp deletion and an inframe insertion of 18 nucleotides, respectively. All but 1 isolate had numerous nonsilent point mutations. These data identify a hypervariable region within the Cterminus of LMP-1, in a domain required for maximal stimulation of NF-κB activity. These data demonstrate that LMP-1-del variants are frequent in acute infectious mononucleosis and tonsillar hyperplasia and identical to those observed in Epstein-Barr virus-associated AIDS-related lymphoma.

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Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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