Journal Article

Cidofovir and Foscarnet for Treatment of Human Herpesvirus 6 Encephalitis in a Neutropenic Stem Cell Transplant Recipient

Christoph Pöhlmann, Johannes Schetelig, Ulrike Reuner, Martin Bornhäuser, Thomas Illmer, Alexander Kiani, Gerhard Ehninger, Enno Jacobs and Jacques Rohayem

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 44, issue 12, pages e118-e120
Published in print June 2007 | ISSN: 1058-4838
Published online June 2007 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/518282
Cidofovir and Foscarnet for Treatment of Human Herpesvirus 6 Encephalitis in a Neutropenic Stem Cell Transplant Recipient

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We report a stem cell transplant recipient who developed human herpesvirus 6 encephalitis. Human herpesvirus 6 load indicated massive intrathecal viral replication. Administration of cidofovir followed by foscarnet was associated with total clearance of human herpesvirus 6 infection. Cidofovir and foscarnet combination therapy may be beneficial for reducing mortality of (neutropenic) stem cell transplant recipients with human herpesvirus 6 encephalitis.

Journal Article.  1716 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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