Journal Article

Cutaneous Leishmaniasis during Pregnancy: Exuberant Lesions and Potential Fetal Complications

Daniel J. Morgan, Luiz H. Guimaraes, Paulo R.L. Machado, Argemiro D'Oliveira, Roque P. Almeida, Ednaldo L. Lago, Daniela R. Faria, Wagner L. Tafuri, Walderez O. Dutra and Edgar M. Carvalho

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 45, issue 4, pages 478-482
Published in print August 2007 | ISSN: 1058-4838
Published online August 2007 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/520017
Cutaneous Leishmaniasis during Pregnancy: Exuberant Lesions and Potential Fetal Complications

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Cutaneous leishmaniasis affects millions of people worldwide. After observations of atypical lesions in pregnant women at the health centers of Corte de Pedra, Brazil, 9 years of records were reviewed, and 26 pregnant patients were identified. A retrospective case-control study revealed that lesions in pregnant women were much larger than those in nonpregnant patients in an age- and sex-matched group (mean area, 6.08 cm2 vs. 1.46 cm2; P = .008), and many lesions had an exophytic nature. Despite foregoing treatment until after delivery, response to pentavalent antimony therapy was favorable (rate of cure with 1 course of treatment, 85%). High rates of preterm births (10.5%) and stillbirths (10.5%) were reported. Cutaneous leishmaniasis during pregnancy produces distinct lesions and may have adverse fetal effects.

Journal Article.  2123 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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