Journal Article

Cure of Implantable Venous Port—Associated Bloodstream Infections in Pediatric Hematology-Oncology Patients without Catheter Removal

Lorry G. Rubin, San Shih, Ashok Shende, Gungor Karayalcin and Philip Lanzkowsky

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 29, issue 1, pages 102-105
Published in print July 1999 | ISSN: 1058-4838
Published online July 1999 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/520135
Cure of Implantable Venous Port—Associated Bloodstream Infections in Pediatric Hematology-Oncology Patients without Catheter Removal

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The efficacy of antibiotic treatment of port-associated bloodstream infection without device removal has not been systematically studied. We analyzed the outcome of 43 consecutive portassociated bloodstream infections in pediatric hematology-oncology patients. Etiologies included Staphylococcus epidermidis (30) and Staphylococcus aureus (6). Antibiotics were given through the port for a median of 11 days. Four ports were removed within 72 hours. In 36 (92%) of the remaining 39 episodes, there was a response to antibiotic therapy (defervescence and negative blood culture). In 78% of episodes in which there was a response (excluding two in which the catheters were removed because of mechanical problems), the infections were cured without port removal. Two of the four relapses were cured with a second course of antibiotics. The cure rate was 92% for S. epidermidis infections and 67% for S. aureus infections. Thus, the majority of port-associated bloodstream infections in pediatric hematology-oncology patients can be cured without device removal.

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Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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