Journal Article

Immune Response to Pneumococcal Conjugate and Polysaccharide Vaccines in Otitis-Prone and Otitis-Free Children

Elizabeth D. Barnett, Stephen I. Pelton, Howard J. Cabral, Roland D. Eavey, Carole Allen, Michael J. Cunningham, Eileen R. McNamara and Jerome O. Klein

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 29, issue 1, pages 191-192
Published in print July 1999 | ISSN: 1058-4838
Published online July 1999 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/520151
Immune Response to Pneumococcal Conjugate and Polysaccharide Vaccines in Otitis-Prone and Otitis-Free Children

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We compared responses to pneumococcal conjugate and polysaccharide vaccines in 48 otitis-free and 64 otitis-prone children. Pre- and postimmunization concentrations of antibodies to pneumococcal serotypes 6B, 14, 19F, and 23F were measured by enzyme-linked immunosorbent assay. Postimmunization mean concentrations of antibodies to all four serotypes were significantly higher for children receiving conjugate vaccine than for those receiving polysaccharide vaccine; the difference in responses was primarily due to a better response to conjugate vaccine in the otitis-prone group. Significantly higher postimmunization concentrations of antibodies to all four serotypes and to one of the four serotypes were found in otitis-prone children and otitis-free children who received conjugate vaccine, respectively. Pneumococcal conjugate vaccine has the potential to reduce the incidence of disease due to vaccine serotypes, even among children with recurrent otitis media.

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Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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