Journal Article

Human Granulocytic Ehrlichiosis in Northern California: Two Case Descriptions with Genetic Analysis of the Ehrlichiae

Janet E. Foley, Leta Crawford-Miksza, J. Stephen Dumler, Carol Glaser, Joon-Seok Chae, Elaine Yeh, David Schnurr, Ron Hood, Willard Hunter and John E. Madigan

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 29, issue 2, pages 388-392
Published in print July 1999 | ISSN: 1058-4838
Published online July 1999 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/520220
Human Granulocytic Ehrlichiosis in Northern California: Two Case Descriptions with Genetic Analysis of the Ehrlichiae

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We report two cases of human granulocytic ehrlichiosis (HGE) that occurred in northern California in summer 1998. Patients had fever, malaise, and myalgia, reported tick bites, had moderate thrombocytopenia, and had normal or slightly elevated liver enzyme activities. Ehrlichial inclusions were observed in the blood of one patient, and HGE-agent DNA was amplified by PCR from both patients. Genetically, the strains resembled horse isolates from northern California. The close spatial and temporal proximity of the two new cases may be due to a nidus of infection in the area or heightened surveillance by local physicians.

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Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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