Journal Article

Pulmonary Toxoplasmosis in Bone Marrow Transplant Recipients: Report of Two Cases and Review

Andreas Sing, Lorenz Leitritz, Andreas Roggenkamp, Hans-Jochem Kolb, Andreas Szabados, Volker Fingerle, Ingo B. Autenrieth and Jürgen Heesemann

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 29, issue 2, pages 429-433
Published in print July 1999 | ISSN: 1058-4838
Published online July 1999 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/520228
Pulmonary Toxoplasmosis in Bone Marrow Transplant Recipients: Report of Two Cases and Review

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Toxoplasma gondii may cause disseminated disease in bone marrow transplant (BMT) recipients. Pulmonary toxoplasmosis in BMT patients is rarely described. Mortality rates of >90% have been previously reported. Since pulmonary toxoplasmosis is extremely difficult to diagnose, it is very often detected only at autopsy. Two cases of pulmonary toxoplasmosis in BMT recipients that were diagnosed by visualization of T. gondii tachyzoites in bronchoalveolar lavage fluid and by a new semi-nested PCR method amplifying 18S rRNA from bronchoalveolar lavage fluid are presented, and the literature on pulmonary toxoplasmosis in BMT patients is reviewed.

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Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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