Journal Article

Epidemiology of Severe Hospital-Acquired Infections in Patients with Liver Cirrhosis: Effect of Long-Term Administration of Norfloxacin

Bernard Campillo, Catherine Dupeyron, Jean-Philippe Richardet, Nicole Mangeney and Georges Leluan

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 26, issue 5, pages 1066-1070
Published in print May 1998 | ISSN: 1058-4838
Published online May 1998 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/520273
Epidemiology of Severe Hospital-Acquired Infections in Patients with Liver Cirrhosis: Effect of Long-Term Administration of Norfloxacin

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We performed a 5-year retrospective study to evaluate the effect of long-term administration of norfloxacin on the epidemiology of severe hospital-acquired infections in patients with advanced cirrhosis. Sixty-seven episodes of spontaneous bacterial peritonitis and 60 episodes of bacteremia occurred in, respectively, 46 patients (group 1a) and 52 patients (group 1b) who did not receive norfloxacin, while 23 and 17 episodes occurred in 21 patients (group 2a) and 17 patients (group 2b) during or within 10 days after long-term administration of norfloxacin. Enterobacteriaceae were more prevalent in groups 1a and 1b than in the other two groups (P < .001 and P < .01, respectively); conversely, staphylococci were more prevalent in groups 2a and 2b (P < .001 and P < .05, respectively). The rate of staphylococcal resistance to methicillin was 53.6% in groups 1a and 1b and 77.3% in groups 2a and 2b. We conclude that long-term norfloxacin administration to cirrhotic patients reduces the risk of gram-negative infections but increases the risk of severe hospital-acquired staphylococcal infections and of high-level resistance to antibiotics.

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Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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