Journal Article

Native Valve Infective Endocarditis in Elderly and Younger Adult Patients: Comparison of Clinical Features and Outcomes with Use of the Duke Criteria and the Duke Endocarditis Database

Jane P. Gagliardi, Richard E. Nettles, David E. McCarty, Linda L. Sanders, G. Ralph Corey and Daniel J. Sexton

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 26, issue 5, pages 1165-1168
Published in print May 1998 | ISSN: 1058-4838
Published online May 1998 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/520304
Native Valve Infective Endocarditis in Elderly and Younger Adult Patients: Comparison of Clinical Features and Outcomes with Use of the Duke Criteria and the Duke Endocarditis Database

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The effect of age on the presentation and outcome of infective endocarditis (IE) is unclear. Many of the available data are based on analyses of mixed populations of patients including intravenous drug users or those with prosthetic valve endocarditis or native valve IE. We used the Duke criteria to compare the characteristics of 44 episodes of definite native valve IE in elderly patients (>64 years old) with the characteristics of 64 similarly defined episodes of native valve IE in younger, nonintravenous-drug-using adult patients (>29 years and <60 years old). Our data suggest that the clinical presentation, characteristics, and outcome of native valve IE are similar for elderly patients and younger adult patients, although elderly patients were hospitalized an average of 12 days longer. Although we found that the occurrence of renal failure and cerebral embolism during an episode of IE was associated with higher rates of death (odds ratios, 4.8 and 4.0, respectively), age was not a significant contributor to mortality.

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Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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