Journal Article

Randomized Trial of Weekly Sulfadoxine/Pyrimethamine vs. Daily Low-Dose Trimethoprim-Sulfamethoxazole for the Prophylaxis of <i>Pneumocystis carinii</i> Pneumonia After Liver Transplantation

J. Torre-Cisneros, M. De la Mata, J. C. Pozo, P. Serrano, J. Briceño, G. Solórzano, G. Miño, C. Pera and P. Sánchez-Guijo

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 29, issue 4, pages 771-774
Published in print August 1999 | ISSN: 1058-4838
Published online August 1999 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/520432
Randomized Trial of Weekly Sulfadoxine/Pyrimethamine vs. Daily Low-Dose Trimethoprim-Sulfamethoxazole for the Prophylaxis of Pneumocystis carinii Pneumonia After Liver Transplantation

More Like This

Show all results sharing these subjects:

  • Infectious Diseases
  • Immunology
  • Public Health and Epidemiology
  • Microbiology

GO

Show Summary Details

Preview

We conducted a prospective, randomized clinical trial among liver transplant patients to assess the efficacy and safety of weekly sulfadoxine/pyrimethamine compared with daily trimethoprimsulfamethoxazole in the prevention of Pneumocystis carinii pneumonia. The studied drugs were given during 6 months after transplantation. One hundred twenty patients were included. None of the 60 patients receiving weekly sulfadoxine/pyrimethamine developed Pneumocystis carinii pneumonia, whereas two cases (3%) developed among the 60 patients who received trimethoprimsulfamethoxazole. For both patients, the studied medication had been discontinued several weeks earlier because of adverse effects. No differences were observed in the incidence of adverse effects. We conclude that weekly sulfadoxine/pyrimethamine is as effective and safe as is daily trimethoprim-sulfamethoxazole in the prophylaxis of Pneumocystis carinii pneumonia after liver transplantation.

Journal Article.  0 words. 

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.