Journal Article

Antilipopolysaccharide II: An Antibody Protective Against Fatal Melioidosis

Chadarat Charuchaimontri, Yupin Suputtamongkol, Churairat Nilakul, Wipada Chaowagul, Ploenchan Chetchotisakd, Nimit Lertpatanasuwun, Sunanta Intaranongpai, Paul J. Brett and Donald E. Woods

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 29, issue 4, pages 813-818
Published in print August 1999 | ISSN: 1058-4838
Published online August 1999 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/520441
Antilipopolysaccharide II: An Antibody Protective Against Fatal Melioidosis

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This was a study of IgG antibody responses to two S-type lipopolysaccharides (LPS I and LPS II) and flagellin of Burkholderia pseudomallei in patients with melioidosis. The specificity of these antibodies was 91.7%, 90.3%, and 93.8%, respectively, when compared to responses in a population where the organism is not endemic. Only the level of antibody to LPS II (anti-LPS II) was significantly higher in patients who survived than in those who died, as well as in patients with nonsepticemic vs. septicemic melioidosis. Results of logistic regression analysis, controlled for confounding factors such as duration of illness before treatment and bacteremic status, confirmed that a high level of anti-LPS II was a significant factor protective against fatal melioidosis. Thus, LPS II of B. pseudomallei would be a potentially useful component of a vaccine developed against fatal melioidosis. Further studies are in progress to determine the level of this antibody among those with asymptomatic infection in areas where melioidosis is endemic.

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Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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