Journal Article

Antibiograms of Multidrug-Resistant Clinical <i>Acinetobacter baumannii</i>: Promising Therapeutic Options for Treatment of Infection with Colistin-Resistant Strains

Jian Li, Roger L. Nation, Roxanne J. Owen, Stephanie Wong, Denis Spelman and Clare Franklin

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 45, issue 5, pages 594-598
Published in print September 2007 | ISSN: 1058-4838
Published online September 2007 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/520658
Antibiograms of Multidrug-Resistant Clinical Acinetobacter baumannii: Promising Therapeutic Options for Treatment of Infection with Colistin-Resistant Strains

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Multidrug-resistant Acinetobacter baumannii infection has presented a global medical challenge. The antibiograms of paired colistin-susceptible and -resistant strains revealed increased susceptibility of colistin-resistant strains to most tested antibiotics, including those that are active against only gram-positive bacteria. Synergy between colistin and rifampicin was observed in the colistin-susceptible strains. The ability to form biofilm in the colistin-resistant strains was significantly lower (P < .001) than in the parent strains. Our study provides valuable information for potential expansion of our current therapeutic options against colistin-resistant A. baumannii infection.

Journal Article.  2433 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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