Journal Article

Psychosis in a 12-Year-Old HIV-Positive Girl with an Increased Serum Concentration of Efavirenz

Elizabeth A. Lowenhaupt, Kelly Matson, Bushra Qureishi, Akihiko Saitoh and David Pugatch

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 45, issue 10, pages e128-e130
Published in print November 2007 | ISSN: 1058-4838
Published online November 2007 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/522764
Psychosis in a 12-Year-Old HIV-Positive Girl with an Increased Serum Concentration of Efavirenz

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Clearance and adverse effects of efavirenz are associated with CYP2B6-G516T polymorphism. Little is known about the prevalence of genotypes and implications for screening in children. We report (to our knowledge, for the first time in a child) the emergence of psychosis in a 12-year old white girl with an increased efavirenz concentration and heterozygous gene polymorphism of the CYP2B6-G516T.

Journal Article.  2182 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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