Journal Article

Tuberculosis after Initiation of Antiretroviral Therapy in Low-Income and High-Income Countries

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 45, issue 11, pages 1518-1521
Published in print December 2007 | ISSN: 1058-4838
Published online December 2007 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/522986
Tuberculosis after Initiation of Antiretroviral Therapy in Low-Income and High-Income Countries

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We examined the incidence of and risk factors for tuberculosis during the first year of highly active antiretroviral therapy in low-income (4540 patients) and high-income (22,217 patients) countries. Although incidence was much higher in low-income countries, the reduction in the incidence of tuberculosis associated with highly active antiretroviral therapy was similar: the rate ratio for months 7–12 versus months 1–3 was 0.48 (95% confidence interval, 0.36–0.64) in low-income countries and 0.36 (95% confidence interval, 0.26–0.50) in high-income countries. A low CD4 cell count at the start of therapy was the most important risk factor in both settings.

Journal Article.  2380 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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