Journal Article

How Science Will Help Shape Future Clinical Applications of Probiotics

Gregor Reid

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 46, issue Supplement_2, pages S62-S66
Published in print February 2008 | ISSN: 1058-4838
Published online February 2008 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/523340
How Science Will Help Shape Future Clinical Applications of Probiotics

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The recent increased interest in probiotics among clinicians has many causes, primarily the concern about the limitations of the current armamentarium of pharmaceutical agents. Although probiotics have been used mostly in dietary supplements and foods to maintain health, scientific and clinical studies are recognizing the potential of some probiotics to be therapeutic in function. Scientific breakthroughs in understanding the source and composition of the human microbiota, the key nutritional factors that influence these microbes, and their immunomodulatory effects; the creation of disease-targeted recombinant strains; the isolation and characterization of signaling molecules that can modulate microbial biofilms and infectious processes; and advances in biomedical engineering that will provide new delivery systems for probiotics will shape the future of clinical applications of probiotics. In time and with rigorous documentation, some probiotics will likely find an important place in medical practice.

Journal Article.  4027 words. 

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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