Journal Article

Chronic Hepatitis B in Italy: New Features of an Old Disease—Approaching the Universal Prevalence of Hepatitis B e Antigen—Negative Cases and the Eradication of Hepatitis D Infection

Evangelista Sagnelli, Tommaso Stroffolini, Alfonso Mele, Michele Imparato and Piero L. Almasio

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 46, issue 1, pages 110-113
Published in print January 2008 | ISSN: 1058-4838
Published online January 2008 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/524074
Chronic Hepatitis B in Italy: New Features of an Old Disease—Approaching the Universal Prevalence of Hepatitis B e Antigen—Negative Cases and the Eradication of Hepatitis D Infection

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We evaluated 1336 hepatitis B surface antigen—positive subjects consecutively observed in 79 Italian hospitals over a 6-month period. The proportion of hepatitis B e antigen—negative cases was 86.4%, that of patients coinfected with hepatitis D virus was 9.7%, and the rate of patients coinfected with hepatitis C virus was 16.8%. Multiple logistic regression analysis showed that age >49 years, alcohol abuse, and anti—hepatitis D virus and anti—hepatitis C virus positivity were independent predictors of progression to liver cirrhosis.

Journal Article.  2264 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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