Journal Article

Persistence of Vaccinia at the Site of Smallpox Vaccination

James F. Cummings, Mark E. Polhemus, Clifton Hawkes, Mary Klote, George V. Ludwig and Glenn Wortmann

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 46, issue 1, pages 101-102
Published in print January 2008 | ISSN: 1058-4838
Published online January 2008 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/524078
Persistence of Vaccinia at the Site of Smallpox Vaccination

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Persistence of vaccinia at vaccination sites may help determine the risk associated with secondary transmission. Culture, PCR, and antigen detection were performed on serial vaccination site swab specimens. On day 21 after vaccination, 37% of volunteers were culture positive, most of whom had received vaccine for the first time. Vaccinia is detectable at least through day 21 after vaccination.

Journal Article.  1366 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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