Journal Article

Tight Regulation of the Epstein-Barr Virus Setpoint: Interindividual Differences in Epstein-Barr Virus DNA Load Are Conserved after HIV Infection

Erwan Piriou, Karel van Dort, Sigrid Otto, Marinus H. J. van Oers and Debbie van Baarle

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 46, issue 2, pages 313-316
Published in print January 2008 | ISSN: 1058-4838
Published online January 2008 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/524079
Tight Regulation of the Epstein-Barr Virus Setpoint: Interindividual Differences in Epstein-Barr Virus DNA Load Are Conserved after HIV Infection

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Healthy individuals carry a constant number of Epstein-Barr virus-infected B cells in the peripheral blood over time. Here, we show that interindividual differences in Epstein-Barr virus DNA levels are maintained after HIV infection, providing evidence for the existence of an individual Epstein-Barr virus setpoint. Immune activation may contribute to the increase in this setpoint after human immunodeficiency virus seroconversion.

Journal Article.  2288 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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