Journal Article

CD4<sup>+</sup> T Cell Depletion in an Untreated HIV Type 1-Infected Human Leukocyte Antigen-B*5801-Positive Patient with an Undetectable Viral Load

Adriana Andrade, Justin R. Bailey, Jie Xu, Frances H. Philp, Thomas C. Quinn, Thomas M. Williams, Stuart C. Ray, David L. Thomas and Joel N. Blankson

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 46, issue 8, pages e78-e82
Published in print April 2008 | ISSN: 1058-4838
Published online April 2008 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/529387
CD4+ T Cell Depletion in an Untreated HIV Type 1-Infected Human Leukocyte Antigen-B*5801-Positive Patient with an Undetectable Viral Load

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We report a case of a patient infected with human immunodeficiency virus type 1 (HIV-1) for 20 years who has experienced CD4+ T cell depletion in spite of maintaining undetectable viral loads. Our data suggest that immune activation can cause CD4+ T cell depletion even when HIV-1 replication appears to be controlled by host factors.

Journal Article.  2529 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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