Journal Article

Hospitalization for Respiratory Syncytial Virus Infection and Invasive Pneumococcal Disease in Danish Children Aged <2 Years: A Population-Based Cohort Study

Lone Graff Stensballe, Thomas Hjuler, Andreas Andersen, Margit Kaltoft, Henrik Ravn, Peter Aaby and Eric A. F. Simoes

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 46, issue 8, pages 1165-1171
Published in print April 2008 | ISSN: 1058-4838
Published online April 2008 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/529438
Hospitalization for Respiratory Syncytial Virus Infection and Invasive Pneumococcal Disease in Danish Children Aged <2 Years: A Population-Based Cohort Study

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Background. Previous population-based studies have reported a temporal association between respiratory syncytial virus (RSV) infection and invasive pneumococcal disease (IPD). We examined this association at an individual level in the Danish population.

Methods. Using registry information about hospitalization for RSV infection and IPD in Denmark, we conducted a prospective, population-based cohort study and examined the associations between hospitalization for RSV infection and IPD.

Results. In our cohort, no persons aged ⩾2 years experienced IPD within 30 days after hospitalization for RSV infection. Among children aged <2 years, children who were hospitalized for RSV infection had a significantly increased risk of IPD during the 30 days after hospitalization, compared with those who were not hospitalized for RSV infection (adjusted rate ratio, 7.1; 95% confidence interval, 3.6–14.3). Likewise, hospitalization for a non-RSV respiratory infection increased the risk of IPD during the 30 days after hospitalization (adjusted rate ratio, 4.5; 95% confidence interval, 2.0–10.0). IPD did not increase the risk of hospitalization for RSV infection among children aged <2 years.

Conclusions. Both recent hospitalization for RSV infection and recent hospitalization for non-RSV respiratory infection increased the risk of IPD among Danish children aged <2 years.

Journal Article.  3925 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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