Journal Article

Infections in 252 Patients with Common Variable Immunodeficiency

Eric Oksenhendler, Laurence Gérard, Claire Fieschi, Marion Malphettes, Gael Mouillot, Roland Jaussaud, Jean-François Viallard, Martine Gardembas, Lionel Galicier, Nicolas Schleinitz, Felipe Suarez, Pauline Soulas-Sprauel, Eric Hachulla, Arnaud Jaccard, Anaelle Gardeur, Ioannis Théodorou, Claire Rabian and Patrice Debré

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 46, issue 10, pages 1547-1554
Published in print May 2008 | ISSN: 1058-4838
Published online May 2008 | e-ISSN: 1537-6591 | DOI: https://dx.doi.org/10.1086/587669
Infections in 252 Patients with Common Variable Immunodeficiency

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Background. Common variable immunodeficiency is characterized by recurrent infections and defective immunoglobulin production.

Methods. The DEFI French national study prospectively enrolled adult patients with primary hypogammaglobulinemia. Clinical events before inclusion were retrospectively analyzed at that time.

Results. From April 2004 through April 2007, 341 patients were enrolled, 252 of whom had received a diagnosis of common variable immunodeficiency; of those, 110 were male, 142 were female, and 228 were white. The median age at first symptoms was 19 years. The median age at common variable immunodeficiency diagnosis was 33.9 years. The median delay for diagnosis was 15.6 years for the 138 patients with initial symptoms before 1990 and 2.9 years for the 114 patients with initial symptoms from 1990 to the time of the study. The most frequent initial symptoms were upper respiratory tract infections: bronchitis (in 38% of patients), sinusitis (36%), pneumonia (31%), and/or bronchiectasis (14%). Overall, 240 patients had respiratory symptoms. Pneumonia was reported in 147 patients; Streptococcus pneumoniae and Haemophilus influenzae were documented in 46 and 17 cases, respectively. Recurrent or chronic diarrhea was reported in 118 patients. Giardia (35 cases), Salmonella (19), and Campylobacter (19) infections were more frequent in patients with undetectable serum immunoglobulin A (P<.001). Sixteen patients developed opportunistic infections. Persistent infections and requirement for antibiotics despite immunoglobulin substitution correlated with severe defect of memory switched B cells (P=.003) but not with immunoglobulin G trough levels (P=.55).

Conclusion. Although reduced within the past decade, the delay of diagnosis of common variable immunodeficiency remains unacceptable. Recurrence of upper respiratory tract infection or pneumonia should lead to systematic evaluation of serum immunoglobulin.

Journal Article.  4071 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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