Journal Article

Changing Patterns in HIV Reverse Transcriptase Resistance Mutations after Availability of Tenofovir

Carmen de Mendoza, Inmaculada Jiménez-Nacher, Carolina Garrido, Pablo Barreiro, Eva Poveda, Angélica Corral, Natalia Zahonero, Juan González-Lahoz and Vincent Soriano

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 46, issue 11, pages 1782-1785
Published in print June 2008 | ISSN: 1058-4838
Published online June 2008 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/588045
Changing Patterns in HIV Reverse Transcriptase Resistance Mutations after Availability of Tenofovir

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Assessment of 1177 human immunodeficiency virus (HIV) resistance genotypes at an HIV/AIDS clinic showed a decrease in the incidence of the K65R mutation, from 15.2% of isolates during the period 2002–2004 to 2.7% of isolates during the period 2005–2006 (P<.001), despite elevated and stable rates of tenofovir use. A reduction in the rate of coadministration of didanosine (from 41.6% of patients in 2004 to 0.8% of patients in 2006; P<.001) largely explained this observation.

Journal Article.  2223 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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