Journal Article

<i>HLA-Bw4</i> Homozygosity Is Associated with an Impaired CD4 T Cell Recovery after Initiation of Antiretroviral Therapy

Andri Rauch, David Nolan, Hansjakob Furrer, Elizabeth McKinnon, Mina John, Simon Mallal, Silvana Gaudieri, Huldrych F. Günthard, Patrick Schmid, Manuel Battegay, Bernard Hirschel, Amalio Telenti and Ian James

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 46, issue 12, pages 1921-1925
Published in print June 2008 | ISSN: 1058-4838
Published online June 2008 | e-ISSN: 1537-6591 | DOI: https://dx.doi.org/10.1086/588479
HLA-Bw4 Homozygosity Is Associated with an Impaired CD4 T Cell Recovery after Initiation of Antiretroviral Therapy

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We assessed the influence of human leukocyte antigen (HLA) alleles HLA-Bw4 and HLA-Bw6 on CD4 T cell recovery after starting successful combination antiretroviral therapy in 265 individuals. The median gains in the CD4 T cell count after 4 years were 258 cells/µL for HLA-Bw4 homozygotes, 321 cells/µL for HLA-Bw4/Bw6 heterozygotes, and 363 cells/µL for HLA-Bw6 homozygotes (P=.01, compared with HLA-Bw4 homozygotes). HLA-Bw4 homozygosity appears to predict an impaired CD4 T cell recovery after initiation of combination antiretroviral therapy.

Journal Article.  2861 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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