Journal Article

Emergence of Carbapenem Resistance in <i>Pseudomonas aeruginosa</i> Isolates from a Patient with Cystic Fibrosis in the Absence of Carbapenem Therapy

Daniel J. Wolter, Dee Acquazzino, Richard V. Goering, Paul Sammut, Noha Khalaf and Nancy D. Hanson

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 46, issue 12, pages e137-e141
Published in print June 2008 | ISSN: 1058-4838
Published online June 2008 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/588484
Emergence of Carbapenem Resistance in Pseudomonas aeruginosa Isolates from a Patient with Cystic Fibrosis in the Absence of Carbapenem Therapy

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The emergence of carbapenem-resistant Pseudomonas aeruginosa in the lung of a patient with cystic fibrosis was evaluated. A single strain of P. aeruginosa persisted during a 3-year study despite antipseudomonal treatment. A stepwise decrease in carbapenem susceptibility leading to resistance was observed in the absence of carbapenem treatment. These data suggest that chronic exposure to unrelated drug classes may be an important determinant for the emergence of carbapenem resistance in P. aeruginosa.

Journal Article.  3018 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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