Journal Article

Poor Outcomes of Chronic Active Epstein-Barr Virus Infection and Hemophagocytic Lymphohistiocytosis in Non-Japanese Adult Patients

Gabe S. Sonke, Inge Ludwig, Hannah van Oosten, Joke W. Baars, Ellen Meijer, Arnon P. Kater and Daphne de Jong

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 47, issue 1, pages 105-108
Published in print July 2008 | ISSN: 1058-4838
Published online July 2008 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/588790
Poor Outcomes of Chronic Active Epstein-Barr Virus Infection and Hemophagocytic Lymphohistiocytosis in Non-Japanese Adult Patients

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Chronic active Epstein-Barr virus infection manifests as a combination of persistent infectious mononucleosis–like symptoms and high viral load in apparently immunocompetent patients. It is closely related to Epstein-Barr virus–associated hemophagocytic lymphohistiocytosis. These 2 abnormal Epstein-Barr virus–associated diseases are seldom reported in individuals other than Japanese children and adolescents. We report a series of 2 adult non-Japanese patients with fatal chronic active Epstein-Barr virus and 1 adult non-Japanese patient with Epstein-Barr virus hemophagocytic lymphohistiocytosis and discuss its pathogenesis and treatment options.

Journal Article.  2102 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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