Journal Article

Detection of Nonnucleoside Reverse-Transcriptase Inhibitor-Resistant HIV-1 after Discontinuation of Virologically Suppressive Antiretroviral Therapy

C. Bradley Hare, John Mellors, Amy Krambrink, Zhaohui Su, Daniel Skiest, David M. Margolis, Sheran S. Patel, Douglas Barnas, Lisa Frenkel, Robert W. Coombs, Francesca Aweeka, Gene D. Morse, David W. Haas, Valerie Boltz, Sarah Palmer, John Coffin and Diane V. Havlir

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 47, issue 3, pages 421-424
Published in print August 2008 | ISSN: 1058-4838
Published online August 2008 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/589867
Detection of Nonnucleoside Reverse-Transcriptase Inhibitor-Resistant HIV-1 after Discontinuation of Virologically Suppressive Antiretroviral Therapy

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Using standard and ultrasensitive techniques, we detected nonnucleoside reverse-transcriptase inhibitor-associated resistance mutations in 11 (20%) of 54 subjects who discontinued virologically suppressive nonnucleoside reverse-transcriptase inhibitor-containing antiretroviral therapy. Resistance was detected in 45% and 14% of subjects with a baseline human immunodeficiency virus type 1 RNA level of 51–400 copies/mL and ⩽50 copies/mL, respectively. Mutations remained detectable for at least 48 weeks in some subjects.

Journal Article.  2423 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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