Journal Article

Initial Human Herpesvirus-8 Rash and Multicentric Castleman Disease

Benjamin Wyplosz, Agnès Carlotti, Lélia Escaut, Nicolas Vignier, Catherine Guettier, Félix Agbalika, Daniel Vittecoq and Nicolas Dupin

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 47, issue 5, pages 684-688
Published in print September 2008 | ISSN: 1058-4838
Published online September 2008 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/590942
Initial Human Herpesvirus-8 Rash and Multicentric Castleman Disease

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We describe a human immunodeficiency virus-infected man with relapsing rashes and reactivation of human herpesvirus-8 (HHV-8) infection, which evolved into multicentric Castleman disease47-5-684Initial skin biopsy revealed infiltrating HHV-8-positive plasmablasts, a subset of which supported lytic infection47-5-684We document the first case, to our knowledge, of HHV-8-induced rash and suggest that circulating plasmablasts drive HHV-8 to target tissues.

Journal Article.  2107 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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