Journal Article

Relationship of <i>Pneumocystis</i> Antibody Response to Severity of Chronic Obstructive Pulmonary Disease

Alison Morris, Mahesh Netravali, Heather M. Kling, Timothy Shipley, Ted Ross, Frank C. Sciurba and Karen A. Norris

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 47, issue 7, pages e64-e68
Published in print October 2008 | ISSN: 1058-4838
Published online October 2008 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/591701
Relationship of Pneumocystis Antibody Response to Severity of Chronic Obstructive Pulmonary Disease

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Pneumocystis colonization has been associated with severity of chronic obstructive pulmonary disease (COPD). The relationship of Pneumocystis antibody status to COPD severity has not been investigated, but antibody levels might relate to both colonization susceptibility and COPD progression. We investigated anti-Pneumocystis antibody titers and airway obstruction in a cohort of patients with COPD. Undetectable anti-Pneumocystis antibody titer was an independent predictor of more-severe airway obstruction, although use of inhaled corticosteroids is a possible confounder of this effect.

Journal Article.  2761 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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