Journal Article

Epidemiology, Pathophysiology, and Treatment of Kaposi Sarcoma—Associated Herpesvirus Disease: Kaposi Sarcoma, Primary Effusion Lymphoma, and Multicentric Castleman Disease

Ryan J. Sullivan, Liron Pantanowitz, Corey Casper, Justin Stebbing and Bruce J. Dezube

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 47, issue 9, pages 1209-1215
Published in print November 2008 | ISSN: 1058-4838
Published online November 2008 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/592298
Epidemiology, Pathophysiology, and Treatment of Kaposi Sarcoma—Associated Herpesvirus Disease: Kaposi Sarcoma, Primary Effusion Lymphoma, and Multicentric Castleman Disease

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Kaposi sarcoma—associated herpesvirus infection is associated with the development of 3 proliferative diseases: Kaposi sarcoma, primary effusion lymphoma, and multicentric Castleman disease. These conditions are also intimately associated with human immunodeficiency virus infection, and important synergistic interactions between these 2 viruses have been described. Despite differences in viral gene expression patterns in each condition, Kaposi sarcoma–associated herpesvirus encodes similar oncogenic proteins that promote the activation of sequential and parallel signaling pathways. Therapeutic strategies have been implemented to target these unique signaling pathways, and this sort of molecular targeting is the focus of many current research efforts. The scope of this review is to present contemporary knowledge about the epidemiology, virology, and immunology of Kaposi sarcoma–associated herpesvirus and to highlight several key oncogene products that may be targets for chemotherapy.

Journal Article.  5079 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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