Journal Article

Association of a Single-Nucleotide Polymorphism in the Pregnane X Receptor (<i>PXR</i> 63396C→T) with Reduced Concentrations of Unboosted Atazanavir

Marco Siccardi, Antonio D'Avolio, Lorena Baietto, Sara Gibbons, Mauro Sciandra, Daniela Colucci, Stefano Bonora, Saye Khoo, David J. Back, Giovanni Di Perri and Andrew Owen

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 47, issue 9, pages 1222-1225
Published in print November 2008 | ISSN: 1058-4838
Published online November 2008 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/592304
Association of a Single-Nucleotide Polymorphism in the Pregnane X Receptor (PXR 63396C→T) with Reduced Concentrations of Unboosted Atazanavir

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This study investigated pregnane X receptor polymorphisms in relation to unboosted atazanavir plasma concentrations in 2 cohorts of patients. The polymorphism 63396T→C predicted concentrations below the minimum effective concentration (150 ng/mL) with odds ratios of 18 (P=.008) and 5.13 (P=.02). Prospective studies determining potential clinical usefulness are now warranted.

Journal Article.  2351 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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