Journal Article

Recovery of Viremic Control after Superinfection with Pathogenic HIV Type 1 in a Long-Term Elite Controller of HIV Type 1 Infection

Andrea Rachinger, Marjon Navis, Sander van Assen, Paul H. P. Groeneveld and Hanneke Schuitemaker

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 47, issue 11, pages e86-e89
Published in print December 2008 | ISSN: 1058-4838
Published online December 2008 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/592978
Recovery of Viremic Control after Superinfection with Pathogenic HIV Type 1 in a Long-Term Elite Controller of HIV Type 1 Infection

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A human immunodeficiency virus type 1 (HIV-1)—infected elite controller (defined as an untreated HIV-1—infected person with a plasma HIV-1 RNA level <50 copies/mL for at least 12 months) who experienced a viremic episode after superinfection regained natural viremic control, although the viral loads in the patient's 2 partners, infected with the same viral strain, were continuously ∼30-fold higher. Thus, host mechanisms seem to be able to repeatedly control HIV-1 replication, halting disease progression.

Journal Article.  2478 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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