Journal Article

Neutrophils May Be a Vehicle for Viral Replication and Dissemination in Human H5N1 Avian Influenza

Yingying Zhao, Min Lu, Lok Ting Lau, Jie Lu, Zifen Gao, Jinhua Liu, Albert Cheung Hoi Yu, Qi Cao, Juxiang Ye, Michael A. McNutt and Jiang Gu

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 47, issue 12, pages 1575-1578
Published in print December 2008 | ISSN: 1058-4838
Published online December 2008 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/593196
Neutrophils May Be a Vehicle for Viral Replication and Dissemination in Human H5N1 Avian Influenza

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The mechanism of systemic spread of H5N1 virus in patients with avian influenza is unknown. Here, H5N1 nucleoprotein and hemagglutinin were identified by immunohistochemistry in the nucleus and cytoplasm of neutrophils in the placental blood of a pregnant woman. Viral RNA was detected in neutrophils by in situ hybridization and enhanced real-time polymerase chain reaction. Therefore, neutrophils may serve as a vehicle for viral replication and transportation in avian influenza.

Journal Article.  2551 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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