Journal Article

New Generation of Inactivated Poliovirus Vaccines for Universal Immunization after Eradication of Poliomyelitis

Konstantin Chumakov, Ellie Ehrenfeld and Stanley Plotkin

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 47, issue 12, pages 1587-1592
Published in print December 2008 | ISSN: 1058-4838
Published online December 2008 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/593310
New Generation of Inactivated Poliovirus Vaccines for Universal Immunization after Eradication of Poliomyelitis

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Twenty years of global polio eradication efforts may soon eliminate the transmission of wild-type poliovirus. However, new information that has been learned about poliovirus, as well as the political realities of a modern world, demand that universal immunity against poliomyelitis be maintained, even after wild-type poliovirus is eradicated. Although 2 excellent vaccines have proven to be highly effective in the past, neither the live-attenuated vaccine nor the currently used inactivated vaccine are optimal for use in the posteradication era. Therefore, concerted efforts are urgently needed to develop a new generation of vaccine that is risk-free and affordable and can be produced on a global scale. Here, we discuss the desired properties of a vaccine and methods to create a new polio vaccine.

Journal Article.  4714 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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