Journal Article

Epidemiology of Invasive Pneumococcal Disease among Adult Patients in Barcelona Before and After Pediatric 7-Valent Pneumococcal Conjugate Vaccine Introduction, 1997–2007

Carmen Ardanuy, Fe Tubau, Román Pallares, Laura Calatayud, María Angeles Domínguez, Dora Rolo, Inmaculada Grau, Rogelio Martín and Josefina Liñares

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 48, issue 1, pages 57-64
Published in print January 2009 | ISSN: 1058-4838
Published online January 2009 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/594125
Epidemiology of Invasive Pneumococcal Disease among Adult Patients in Barcelona Before and After Pediatric 7-Valent Pneumococcal Conjugate Vaccine Introduction, 1997–2007

More Like This

Show all results sharing these subjects:

  • Infectious Diseases
  • Immunology
  • Public Health and Epidemiology
  • Microbiology

GO

Show Summary Details

Preview

Background. A dramatic decrease in the incidence of invasive pneumococcal disease (IPD) was observed among children and adults in the United States after the introduction of the 7-valent pneumococcal conjugate vaccine (PCV7). Little is known about the incidence of IPD after PCV7 licensure in Europe. The objective of this study was to examine changes in the prevalence of IPD among adults in the PCV7 era.

Methods. We undertook a prospective study involving adults with IPD who required hospital admission in the southern area of Barcelona, Spain. Three periods were studied: the pre-PCV7 period (1997–2001), the early PCV7 period (2002–2004), and the late PCV7 period (2005–2007).

Results. A total of 1007 episodes of IPD were observed. Rates of IPD among adults increased from 13.9 to 14.6 episodes per 100,000 population between the pre-PCV7 period and the early PCV7 period (P=.6) and then to 19.55 episodes per 100,000 population in the late PCV7 period (P<.001). The rates of IPD among adults due to non-PCV7 serotypes increased from 8.4 to 9.7 episodes per 100,000 population between the pre-PCV7 period and the early PCV7 period (P=.15) and then to 15.3 episodes per 100,000 population in the late PCV7 period (P<.001); IPD due to PCV7 serotypes decreased from 5.6 to 4.9 episodes per 100,000 population between the pre-PCV7 period and the early PCV7 period (P=.3), then to 4.3 episodes per 100,000 population in the late PCV7 period (P=.056). Among people aged ⩾65 years, IPD due to PCV7 serotypes decreased from 19.5 to 14.6 episodes per 100,000 population between the pre-PCV7 period and the early PCV7 period (P=.13), then to 12.3 episodes per 100,000 population in the late PCV7 period (P=.02). A decrease in the prevalence of antibiotic-resistant pneumococci in the late PCV7 period was associated with a decrease in the prevalence of multidrug-resistant PCV7 clones (Spain23F-ST81, Spain6B-ST90, and ST8819F) and an increase in the prevalence of non-PCV7 antibiotic-susceptible clones (ST3061, ST1917F, ST98912F, and ST43322F).

Conclusions. Rates of IPD among adults increased in Barcelona in the late PCV7 period, coinciding with a clonal expansion of non-PCV7 serotypes. In contrast, rates of IPD caused by PCV7 serotypes decreased among people aged ⩾65 years, which suggests the development of a herd immunity.

Journal Article.  4935 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.