Journal Article

Diagnosis of Neurocysticercosis by Detection of <i>Taenia solium</i> DNA Using a Global DNA Screening Platform

Amanda T. Harrington, Claire J. Creutzfeldt, Dhruba J. SenGupta, Daniel R. Hoogestraat, Joseph R. Zunt and Brad T. Cookson

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 48, issue 1, pages 86-90
Published in print January 2009 | ISSN: 1058-4838
Published online January 2009 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/594128
Diagnosis of Neurocysticercosis by Detection of Taenia solium DNA Using a Global DNA Screening Platform

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Neurocysticercosis is caused by Taenia solium infection of the brain. Diagnosis is most often made by visualization of the parasitic scolex by magnetic resonance imaging of the brain or by characteristic neuroimaging findings with serologic test results positive for T. solium. A patient who presents with a solitary brain lesion usually poses a diagnostic dilemma, because the differential diagnosis often includes neurocysticercosis and other infections or neoplasm. Although the sensitivity of serologic testing for T. solium approaches 100% in patients with multiple intraparenchymal cysts, the sensitivity of testing for patients with solitary cysts is <50%, which makes serologic testing a less useful diagnostic tool for patients with solitary central nervous system (CNS) lesions. We describe 2 patients with solitary CNS lesions who received a neurocysticercosis diagnosis after identification of T. solium DNA in brain biopsy tissue with use of a global DNA screening platform. Global screening is a promising tool for the diagnosis of CNS infection, especially when traditional diagnostic tools are insensitive.

Journal Article.  2403 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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