Journal Article

Should HLA-B*5701 Screening Be Performed in Every Ethnic Group before Starting Abacavir?

Wan Beom Park, Pyoeng Gyun Choe, Kyoung-Ho Song, Shinwon Lee, Hee-Chang Jang, Jae Hyun Jeon, Sang-Won Park, Myoung Hee Park, Myoung-don Oh and Kang Won Choe

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 48, issue 3, pages 365-367
Published in print February 2009 | ISSN: 1058-4838
Published online February 2009 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/595890
Should HLA-B*5701 Screening Be Performed in Every Ethnic Group before Starting Abacavir?

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Human leukocyte antigen allele (HLA)–B*5701 is associated with abacavir hypersensitivity. However, the carriage rate of HLA-B*5701 has rarely been studied in Asians. In 534 Korean patients with human immunodeficiency virus infection, HLA-B*5701 status was determined by polymerase chain reaction with HLA-B*5701–specific primers. No patients had the HLA-B*5701 allele (95% confidence interval, 0%–0.7%). This explains the paucity of immunologically confirmed cases of abacavir hypersensitivity in Koreans.

Journal Article.  1879 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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