Journal Article

Antimicrobial and Immunomodulatory Attributes of Statins: Relevance in Solid-Organ Transplant Recipients

Hsin-Yun Sun and Nina Singh

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 48, issue 6, pages 745-755
Published in print March 2009 | ISSN: 1058-4838
Published online March 2009 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/597039
Antimicrobial and Immunomodulatory Attributes of Statins: Relevance in Solid-Organ Transplant Recipients

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Statins are increasingly being used to treat solid-organ transplant recipients for posttransplantation metabolic complications. In addition to improving dyslipidemia, statins also have manifold non–lipid-lowering effects. With regard to sepsis or infection, these agents modify the inflammatory cascades by pleiotropic actions at multiple levels and exhibit activities against opportunistic bacteria, fungi, and viruses that can cause serious infections in solid-organ transplant recipients. They also have synergistic interactions with antimicrobial agents. Statins with antimicrobial and immunomodulatory attributes might improve morbidity and mortality attributable to sepsis or infection in solid-organ transplant recipients.

Journal Article.  7775 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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