Journal Article

Association of Single-Nucleotide Polymorphism 3 and c.553G>T of <i>APOA5</i> with Hypertriglyceridemia after Treatment with Highly Active Antiretroviral Therapy Containing Protease Inhibitors in HIV-Infected Individuals in Taiwan

Sui-Yuan Chang, Wei-Shin Ko, Jau-Tsuen Kao, Lan-Yang Chang, Hsin-Yun Sun, Mao-Yuan Chen, Szu-Min Hsieh, Wang-Huei Sheng, Shu-Fang Chang, Wen-Chun Liu, Cheng-Hsin Wu, Hui-Jen Hsu, Chuan-Liang Kao, Chun-Nan Lee, Chien-Ching Hung and Shan-Chwen Chang

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 48, issue 6, pages 832-835
Published in print March 2009 | ISSN: 1058-4838
Published online March 2009 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/597099
Association of Single-Nucleotide Polymorphism 3 and c.553G>T of APOA5 with Hypertriglyceridemia after Treatment with Highly Active Antiretroviral Therapy Containing Protease Inhibitors in HIV-Infected Individuals in Taiwan

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We investigated the relationship between hypertriglyceridemia and the single-nucleotide polymorphisms (SNPs) on APOA5 in human immunodeficiency virus (HIV)–infected patients receiving highly active antiretroviral therapy (HAART) in Taiwan. Receipt of protease inhibitor–based HAART, high baseline triglyceride levels, and carriage of APOA5 SNP3 or c.553G>T variants or APOA5 SNP1T/SNP2G/SNP3C/c.553T haplotype were statistically significantly associated with development of extreme hypertriglyceridemia (triglyceride level, >500 mg/dL).

Journal Article.  2217 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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